Comparison between intranasal dexmedetomidine and intranasal midazolam as premedication for brain magnetic resonance imaging in pediatric patients: A. Intranasal dexmedetomidine has been used an effective and safe alternative premedication to oral midazolam in children. At a dose of 2micrograms/kg. Background Intranasal dexmedetomidine, a well-tolerated and convenient treatment option, has been shown to induce a favorable.

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The level of sedation and vital signs were documented every 3 to 5 minutes. Premedication with midazolam in young children: Disclosure The authors declare no conflicts or financial interest in any product or service mentioned in the manuscript, including grants, equipment, medications, employment, gifts, and honoraria.

Intranasal Dexmedetomidine

Thanks dexmedetomidin the interesting topic. We observed successful parental separation in This can present a problem for very busy sedation services that require rapid patient turnover time.

A double blind RCT. J Anaesthesiol Clin Pharmacol. Comparison of two different intranasal doses of dexmevetomidine in children for magnetic resonance imaging sedation. How do I use the MAD device?

The success of magnetic resonance imaging MRI as a diagnostic tool has led to its increased use in patients of all age groups; however, children undergoing MRI often require sedation because the magnetic field creates a sound of a very high decibel and to minimize motion artifact. In another study by Mostafa and Morsy comparing the use of dexmedetomidine, midazolam, and ketamine as intranasal premedication, the percentage of children who achieved child—parent separation score Grade 1 was Dexmedetomidine for pediatric sedation for computed tomography imaging studies.


Group M received intranasal midazolam 0. National Center for Biotechnology InformationU. Preanesthetic assessment included medical and surgical history; general and systemic examination; airway examination; and investigations, such as complete hemogram and renal function tests, conducted on an outpatient basis.

Intranasal Dexmedetomidine | Pediatric Sedation Blog

The baseline HR was comparable between the groups [ Figure 1 ]. An effective route of sedation preserves background activity for pediatric electroencephalograms. The level of sedation was noted as either moderate or deep in 31 and 78 dexmrdetomidine, respectively.

Subjects were contacted the night before the procedure and were given relevant instructions regarding when and where to arrive and fasting time. We compared hemodynamic and respiratory parameters, onset, level, sedation quality, and successful parental separation.

Methods This was a prospective observational study, performed in our procedural suite, located at a tertiary medical center. Time of induction was noted, and whether parental separation at the time of induction was successful was recorded.

A randomised comparison of two intranasal dexmedetomidine doses for premedication in children. In addition to the IN dexmedetomidine, we have found that if we combine it with intranasal midazolam 0.

Our secondary objective was to evaluate the safety profile of IN DEX compared to well-established intravenous sedative medications i. A comparison of four routes of administration.

However, it is my belief that IN dexmedetomidine given alone or in combination with another drug such as ketamine may have broad application for sedation in children. Median sedation scores for Groups M and D were 4 and 3, respectively [ Figure 4 ].

Optimal timing for the administration of intranasal dexmedetomidine for premedication in children.

The non-DEX cohort had a longer preprocedure time, which may have been due to variations related to the of preprocedure protocols. Sedation nurses also documented sedative medications used for the procedure, level of sedation Table 1and observed events. The patients were randomly allocated dexmeretomidine two groups.


J Clin Pediatr Dent.

It is important to emphasize that this approach should be adopted only in a setting in which the child is monitored and medications administered by a trained skilled provider. We have noticed it takes most patients about 30 minutes to fall asleep and we get about dexmedetomifine hour of deep sedation out of it. A subgroup analysis of procedure times found no statistical difference in subjects who had received additional IN midazolam compared to those given IN DEX alone; however, the sample size lacked adequate power.

In addition, the use of the nasal MAD mucosal atomization device has allowed quick and even administration of the drug.

Optimal timing for the administration of intranasal dexmedetomidine for premedication in children.

Onset occurred in minutes with a peak effect at 90 minutes. A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: For induction, an intravenous bolus of 0. The child in fact slept through the duration of the scan without additional medication or anesthesia.

J Int Med Res.