Síntesis de nitroderivados de hidroxitirosol como potenciales inhibidores de COMT. Article in Basic & Clinical Pharmacology & Toxicology · January . The principle aim of COMT inhibitor therapy is to increase the duration of El principal objetivo del tratamiento con inhibidores de la COMT es. AMPT: α-metil-p-tirosina; COMT: catecol-O- . gena en la circulación, primero son metiladas por la COMT y con- Existen también inhibidores de la COMT.

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Catechol-O-methyltransferase – Wikipedia

As the regulation of catecholamines is impaired in a number of medical inhkbidores, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines. Catechol- O -methyltransferase is involved in the inactivation of the catecholamine neurotransmitters dopamineepinephrineand norepinephrine. The enzyme introduces a methyl group to the catecholamine, which is donated by S-adenosyl methionine SAM. Any compound having a catechol structure, like catecholestrogens and catechol-containing flavonoids, are substrates of COMT.

Levodopaa precursor of catecholamines, is an important substrate of COMT.

When given with an inhibitor of dopa decarboxylase carbidopa or benserazidelevodopa is optimally saved. This “triple therapy” is becoming a standard in the treatment of Parkinson’s disease. In the brain, COMT-dependent dopamine degradation is of particular importance in brain regions with low expression of the presynaptic dopamine transporter DATsuch as the prefrontal cortex.

The gene is associated with allelic inihbidores. The best-studied is ValMet.

inhibidlres A functional single-nucleotide polymorphism a common normal variant of the gene for catechol-O-methyltransferase results in a valine to methionine mutation at position Val Met rs Given the preferential role of COMT in prefrontal dopamine degradation, the ValMet polymorphism is thought to exert its effects on cognition by modulating dopamine signaling in the frontal lobes.


The gene variant has been shown to affect cognitive tasks broadly related to executive functionsuch as set shifting, response inhibition, abstract thought, and the acquisition of inhibidires or task structure. Comparable effects on similar cognitive tasks, the frontal lobes, and the neurotransmitter lla have also all been linked to schizophrenia.

It is increasingly recognised that allelic variation at the COMT gene are also relevant for emotional processing, as they seem to influence the interaction between prefrontal and limbic regions.

Research conducted at the Section of Neurobiology of PsychosisInstitute of Psychiatry, King’s College London has demonstrated an effect of COMT both in patients with bipolar disorder and in their relatives, [36] [ unreliable medical source ] comtt these findings have not been replicated so far. The effect size of genotypic moderation was quite large: Genetic variation with functional impact on cortical dopamine tone has a strong influence on reward experience in the flow of daily life.

Temporomandibular joint dysfunction TMD does not inhibidorees to be a classic genetic disorder, however variations in the gene that codes for COMT have been suggested to be responsible for inheritance of a predisposition to develop TMD during domt.

COMT is the name given to the gene that codes for this enzyme. The O in the name stands for oxygennot for ortho. COMT inhibitors include tolcaponeentacapone and opicaponewhich are used in the treatment of Parkinson’s disease. From Wikipedia, the free encyclopedia. This article relies too much on references to primary sources. Please improve this by adding secondary or tertiary sources.

December Learn how and when to remove this template message. Student consult 7th ed. Retrieved November 16, Goetz CG May Neurotransmitters and their receptors”. The Central Nervous System.

COMT inhibition in the treatment of Parkinson’s disease.

The Journal of Biological Chemistry. Principles of pharmacology 3rd ed. Journal of Alzheimer’s Disease.


The American Journal of Psychiatry. American Journal inhibidorfs Human Genetics. The British Journal of Psychiatry. Lay summary — MedWireNews. Journal of Oral Rehabilitation. Two of the nitrocatechols, entacapone However, tolcapone is clinically restricted owning to its increased hepatotoxicity and other related al disorders. Journal of Neural Transmission.

Zhu BT October Oroszi G, Goldman D December Enzymes involved in neurotransmission.

COMT inhibition in the treatment of Parkinson’s disease.

Histamine N-methyltransferase Diamine oxidase. Tyrosine hydroxylase Aromatic L-amino acid decarboxylase Dopamine beta-hydroxylase Phenylethanolamine N-methyltransferase. Catechol-O-methyl transferase Monoamine oxidase A B. Tryptophan hydroxylase Aromatic L-amino acid decarboxylase Aralkylamine N-acetyltransferase Acetylserotonin O-methyltransferase. Cholinesterase AcetylcholinesteraseButyrylcholinesterase. Histamine N-methyltransferase Phenylethanolamine N-methyltransferase Amine N-methyltransferase Phosphatidylethanolamine N-methyltransferase.

Betaine-homocysteine methyltransferase Homocysteine methyltransferase Methionine synthase. Serine hydroxymethyltransferase 3-methyloxobutanoate hydroxymethyltransferase.

Phosphoribosylglycinamide formyltransferase Inosine monophosphate synthase. Aspartate carbamoyltransferase Ornithine carbamoyltransferase Oxamate carbamoyltransferase Putrescine carbamoyltransferase 3-hydroxymethylcephem carbamoyltransferase Lysine carbamoyltransferase N-acetylornithine carbamoyltransferase.

Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator. EC number Enzyme superfamily Enzyme family List of enzymes. Molecular and Cellular Biology portal. Retrieved from ” https: Genes on human chromosome 22 EC 2. All articles with dead external links Articles with dead external links from November Articles with permanently dead external links Articles lacking reliable inhiidores from December All articles lacking reliable references Commons category link is on Wikidata.

Views Read Edit View history. In other projects Wikimedia Commons. This page was last edited on 21 Novemberat By using this site, you agree to the Terms of Use and Privacy Policy. Available structures PDB Ortholog search: Chromosome 22 human [1].

More reference expression data. Hydroxymethyltransferase Serine hydroxymethyltransferase 3-methyloxobutanoate hydroxymethyltransferase.