FORMULASI SUSPENSION PDF

Keywords: Dry suspension, Taste Masking, Macrolide Antibiotic, Eudragit L . formula F = Vu/Vo, where Vu is the volume of sediment and Vo. Route Dosage Form. Concentration. Sulfamethoxazole-Trimethoprim Oral Suspension 40mg/5mL. Formula Qty: mL. Shelf Life: 20 days. Hospital Of Eastern Ontario. MASTER FORMULA SHEET – NON-STERILE MANUFACTURING. PRODUCT: PROPRANOLOL 5 mg/mL ORAL SUSPENSION .

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Formulation of cefuroxime axetil oral suspension and investigation of its pharmaceutical properties

A new approach to HPLC analysis of medicinal suspensions. Tabibi S, Rhodes CH. The viscosity curves showed that the systems were pseudo plastic and thixotrop.

Eur J Pharm Xuspension. Then using equation derived from calibration curve. Other tests, including measurement of pH, viscosity and zeta potential measurements were performed and finally the best formulations were selected. General criteria for selecting a suitable suspension can be considered as proper appearance of uniformity and homogeneity, the number of low-frequency shaking for the complete distribution, the high volume of sediment, no crystal growth and appropriate pour ability.

For the assay solution 5 ml of suspension was dissolved in 50 ml methanol and after shaking for 5 minutes ml of medium was added and after achieving Considering the differences of the viscosity in up and down curves the thixotropy of the system is obvious so the vehicle was pseudo plastic and thixotrop.

Conclusion According to the obtained results and considering the ideal characteristics of prepared suspension formulations, this product can be added to drug market.

Preparation of amorphous cefuroxime axetil nanoparticles by sonoprecipitation formulassi enhancement of bioavailability. An advantage of cefuroxime over other second-generation cephalosporins is that it is effective in the treatment of Neisseria gonorrhea and H influenzae. Eur J Pharm Sci.

For 3 of each formulation, dissolution test was performed with USP 2 apparatus Paddle in 50 rpm for 30 minutes. Since cefuroxime is not absorbed orally, the 1-acetyloxyethyl axetil ester of cefuroxime was used to improve its gastrointestinal absorption. Cefuroxime is the second generation cephalosporin, suspensino its intravenous and oral dosage forms are available.

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A sample viscosity curve for formulated suspension. From all 33 formulations designed in Minitab software, only 9 was selected to further investigation that are listed in the Table 1. Designed cefuroxime axetil formulations had good qualities and could be added as a new product to Iran drug marketing. All other chemicals were purchased fromMerck, Darmstadt, Germany.

This article has been cited by other articles in PMC. One of the methods for making the suspension, is the dispersion of a particle in a vehicle that can be done by mechanical instruments or by the use of surfactants that contains three steps: Quantity of zeta potential can indicate the potential stability of the colloidal system, if the particles have a large positive or negative zeta potential they will have a tendency to repel each other and in too low zeta potentials particles will accumulate and attract each other.

Table 2 Results of assay test. The stability of the amorphous form of cefuroxime axetil in solid state. Port City Press; Journal List Adv Pharm Bull v.

Formulation of cefuroxime axetil oral suspension and investigation of its pharmaceutical properties

According to the viscosity curves, the suspensions were pseudo plastic, i. From all 33 formulations, only 9 were selected to further investigation. It is characterized by being the only second-generation cephalosporin which adequately penetratesinto the cerebrospinal fluid CSF. Prepared formulations were evaluated by UV system in wavelengths, for the standard solution 20 mg of the drug was dissolved in 50 ml methanol and Open in a separate window.

Discussion General criteria for selecting a suitable suspension can be considered as proper appearance of uniformity and homogeneity, the number of low-frequency shaking for the complete distribution, the high volume of sediment, no crystal growth and appropriate pour ability.

Published online Dec Acknowledgement The authors would like to thank Dana Pharmaceutical Co. Oral route is the selective method for administration of most of the drugs. The sedimentation volume was calculated to be 1 in all the suspensions, therefore there was no need to re-dispersion test and the degree of flocculation value was also 1. There was no sediment in selected formulations and the sediment volume was 1 for all of them so there was no need for re-dispersion test and the degree of the flocculation was also 1 that was probably because of the high viscosity of the system.

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Martin’s Physical Pharmacy and Pharmaceutical Sciences. According to these properties a general discussion is presented. Tabriz, Iran for the supply of cefuroxime axetil.

Influence of the soluble solids on the zeta potential of the cloudy apple juice. The charge of the particles effects their distribution in the environment and increases the concentration of opposite charge on the surface close to them which produces electric double layer. Bioequivalence evaluation of two brands of cefuroxime mg tablets cefuzime and zinnat in healthy volunteers. The potential of the moving layer around each particle is called zeta potential.

Percent of labeled amount. After selecting the acceptable preparations, physical stability tests and other tests such as dissolution rate, pH, zeta potential and viscosity measurement of formulations were performed.

Remington the science and practice of Pharmacy. Pharmacokinetic models for the saturable absorption of cefuroxime axetil and saturable elimination of cefuroxime suspemsion. For suspension formulation equivalent to mg of cefuroxime was suspended in 5 ml vehicle, after selecting the type and concentration of wetting agent, other ingredients such as flocculating agents, suspending agents, preservatives and flavors were added.

According to the curve each formulation released