Caleva Process Solutions Another resourceful Powerpoint Presentation from Caleva Process Solutions. These selection. Advancements in Extrusion-Spheronization. More agile techniques are improving the development of multiparticulate drug-delivery systems. Extrusion Spheronization is one of them and utilized in formulation of beads and pellets. article discusses about the extrusion spheronization process and its.

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The optimized pellets were evaluated for their particle size distribution using the laser light diffraction instrument Malvern Instruments, Mastersizer Ver. But, after 5M slight change in color and fishy odor was developed at accelerated stability studies.

Brain Res Dev Brain Res. Choline bitartrate was used as a core material and HSO as a coating agent which coat the drug. Please note that Lonza has updated its Privacy Policy.

Stability studies of pellets containing encapsulated F5 exhibited no signs of discoloration or fishy odor development after 4M on storage at accelerated conditions.

Samples were reevaluated after 1, 2, 3, 4, 5, and 6M for physical appearance, discoloration, fishy odor development resembling amines, moisture content, and drug content.

Extrusion & Spheronization Pharmaceutical Technology

No significant change spehronization weight was observed after subjecting the sample to accelerated conditions of temperature and humidity. Int J Pharm Spberonization Sci.

Hydrogenated soya bean oil has low melting point so when it is used in other techniques such as fluidized bed processor or spray drying the material got stuck to the expansion chamber during drying process and the nozzle gun also blocked during coating process. Read more about it here! To formulate a pellet with desired characteristics physical appearance and sphericitythe parameters such as speed of spheronization, temperature of jacketed spheronizer, and time of edtrusion were varied in the range as mentioned in Table 1.

Richardson P, Hernandez L. Fluidized bed coating in food technology. The technology chosen is dependent upon multiple active ingredient and formulation criteria, e.

Furthermore, the solvent required in this technique is very less as compared to other techniques. For the determination of drug content factor given in USP was used.


The diffractograms of optimized pellets of F5 and F10 showed broad peaks with low intensities, which may attributed to the incorporation of CBT with wax, leading to a slight shift in height of peaks. The ratio of liquid to solid material together with the size of the extruder holes significantly determines spheronizatioj quality of the extrudates.

The 5 h release of encapsulated CBT was sphernoization out to determine whether the coating offers significant protection to the choline for its stabilization.

Extrusion / Spheronization

We also use cookies on our websites. Pellets spherpnization with HPMC 15 cps showed good compressibility index, hardness-friability index HFIand flow properties as compared to other binders. By Product Development Site. The heater was placed in such way that it is above the die plate and uniformly supplies the heat through conduction. Am J Clin Nutr. Hardness-friability index was calculated on the basis of the results of the friability test.

Formulation and evaluation of aceclofenac loaded SR matrix pellets: The current spheronizatiob focuses on the process of extrusion-spheronization and the operational extruder types, screen pressure, screw speed, temperature, moisture content, spheronization load, speed and time and formulation excipients and drugs variables, which may affect the quality of the final pellets. But, compressibility and binding capacity of pellets were relatively low therefore addition of sphefonization binder required to be added in formulation composition.

In vitro drug release The 5 h release rxtrusion encapsulated CBT in water was determined as 1 g of CBT was placed in ml of elementary flask containing ml of distilled water and flask was sealed with a stopper.

Therefore, nature of coating offered significant protection when the encapsulate choline exposed to water for 5 h.

Powder X-ray diffractometry analysis The powder X-ray diffractograms are shown in Figure 5. Where, F b and F a are weights before and after friability treatment, respectively. Choline availability modulates the expression of TGFbeta1 and cytoskeletal proteins in the hippocampus of developing rat brain.

Extrusion / Spheronization – Glatt Integrated Process Solutions

Habich A, Hansen MM. It also offers immense pharmaceutical applicability due to the benefits of high loading capacity of active ingredient snarrow size distribution, and cost-effectiveness. Formulation, optimization, characterization and in vitro evaluation. By clicking “I Agree”, you confirm that you are above the age of 16, that you have read and understood the Privacy Policy and the Cookies Policy, and that you agree to the collection, use and processing of your Personal Information by Lonza in accordance with said policies.


Sintering of wax for controlling release from pellets. By visiting our website or using services provided by Lonza, you are accepting the practices described in the Privacy Policy.

Optimized formulation was kept for 6 months stability study as per ICH guidelines, and there was no change in color, moisture content, drug content, and no fishy odor was observed.

The use of organic solvent is associated with the environmental problem, solvent residue, and excessive cost of recovery, whereas aqueous solvent generally prolongs the duration of coating process. Asian J Pharm Anal. Similarly, at higher spheronization speed pellets get agglomerated due to melting of HSO at higher temperature.

The aspect ratio of pellets varied from 1. The different trials for wax coating were conducted and based on these trials the preliminary processing variables for wax coating were selected. The samples were ground thoroughly with potassium bromide at 1: Development of novel ibuprofen loaded solid dispersion with improved bioavailability using aqueous solution.

Dosage form containing stabilized choline and methods for spheronizwtion the same. For technical reasons, the resulting pellets are spheronizatioj than micrometers. You can disable cookies but parts of our website may not work. Assay of CBT was determined by potentiometric titration method. The dry, mixed, powdery active substances are kneaded into a dough with a liquid. Choline availability alters embryonic development of the hippocampus and septum in the rat.

In the current study, CBT is microencapsulated with a lipid wax, hydrogenated vegetable oil Soya bean oil. Volume weighted mean particle size, the d 0.