Management of Benzodiazepine Withdrawal – WS DASSA August Benzodiazepine equivalents. Name. Duration of. Action #. Approx dose. Alprazolam. Xanax. Y**. B. Chlordiazepoxide Librium. Y**. B,E. Clonazepam. Klonopin. – N**. A,B,D,E. Diazepam. Valium. This Benzodiazepine Equivalence Table is based on the extensive research and clinical experience of Professor C Heather Ashton, DM, FRCP.

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References Ashton Curr Opin Psychiatry Benzodiazepine Equivalents Conversion Benzodaizepine. Lieberman JA, Tasman A. Benzodiazepines have a narrow therapeutic window – dose adjustments should be made by an experienced clinician. Absolute bioavailability of oral and intramuscular diazepam: Indications Benzodiazepine Withdrawal Barbiturate withdrawal Sedative withdrawal. Content is updated monthly with systematic literature reviews and conferences.

The following guiding principles govern the calculator’s logic:.

We’ve filled out some of the form to show you this clinical calculator in action. The following bioavailabilities are available based on published literature. Handbook of Psychiatric Drugs.

While barbiturates do share similar pharmacology to benzodiazepines, they have a more concerning safety profile with a higher incidence of respiratory depression. Updated June 3, Search other sites for ‘Benzodiazepine Equivalents’. Search Bing for all related images. All benzodiazepine conversions used in this calculator are based on published equipotent dose estimates.


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Related links to external sites from Bing. Although phenobarbital and secobarbital are not benzodiazepines, they are commonly grouped with this drug class and cited within benzodiazepine conversion charts due to their use in alcohol withdrawal.

Home Academy Blog About. Most benzodiazepines included in this calculator are only available as oral dosage forms.

Phenobarbital pharmacokinetics and bioavailability in adults. A Comprehensive Study Guide.

Dose equivalence of midazolam and triazolam. Evaluation of an alcohol withdrawal protocol and a preprinted order set at a tertiary care hospital. Patients should address specific medical concerns with their physicians. Back Links pages that link to this page.

Equivalent Benzodiazepine Calculator

Barbiturate Abuse Benzodiazepine Abuse. These images are a random sampling from a Bing search on the term “Benzodiazepine Equivalents. Unlike nearly all other benzodiazepine conversions, the conversion between intravenous midazolam and lorazepam has been well studied in mechanically ventilated patients. Effect of age, gender, and obesity on midazolam kinetics. For more information, please view the website disclaimer.

Started inthis collection now contains interlinked topic pages divided into a tree of 31 specialty books and chapters. Due to discrepancies in the literature, many benzodiazepine conversions may have a potential conversion range that is extremely variable eg, by a factor of 10x or greater. Eur J Clin Pharmacol. Unlike opioid equipotent dosingbenzodiazepine equivalence is much less evidence-based and poorly described equivzlency the literature.


Can J Hosp Pharm.

Page Contents Page Contents These wide ranges of confidence highlight the lack of firm, evidence-based literature supporting specific conversion benzodiazeine. This calculator is not a substitute for clinical experience and must be used in conjunction with reasonable clinical judgment. Bioavailability of diazepam after intravenous, oral and rectal administration in adult epileptic patients. Benzodiazepines Equivalents Alprazolam Xanax Alprazolam 0.

Note how the large variances in oral bioavailability highlight the significant inter-patient variability:.

Benzodiazepine Equivalents

Because published benzodiazepine dose conversions are based on oral administration, parenteral formulations may not use the same conversion ratio.

A double-blind, randomized comparison of i. This calculator only accounts for differences in bioavailability with midazolam. Related Bing Images Extra: